[CvGmt News] [Notiziario] [Settimanale] seminario Alberto d'Onofrio 23-02-12 ore 14

[Liviana Paoletti]

GIOVEDI' 23 FEBBRAIO 2012 

SEMINARIO
14:00-16:00, Sala Riunioni (Dip. Matematica)
The mathematics of viral hepatitis B and C 
A. d'Onofrio (Istituto Europeo di Oncologia, Milano)



Abstract:
Probably the most important case of a mathematical model that 
influenced medicine (both in basic research and in clinics) is given 
by the mathematical models of HCV and HBV dynamics and of antiviral
therapies.
I will review some of them (mainly those by the Perelson's and 
Bonino's research groups, and mainly focusing on HCV) by stressing 
the current "grand challenge":
how to use and improve those models in order to understand the 
problem of the disease-relapse during and after the antivial 
therapies ?
In particular, I will stress how apparently abstract mathematical 
concepts (global asymptotic stability, Floquet's eigenvalues, optimal 
control, hybrid gillespie algorithms, delay differential equations) 
map into practical clinical problems (disease erdication, drug 
schedulings, late and ultra-late disease relapse). 


  



Liviana Paoletti 
  Segreteria Scientifica

Dipartimento di Matematica
"L. Tonelli" Universita' di Pisa
tel. 0502213251
e-mail  paoletti at dm.unipi.it
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