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<H3>GIOVEDI' 23 FEBBRAIO 2012 </H3></FONT>
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<P><B>SEMINARIO</B><BR>14:00-16:00, Sala Riunioni (Dip. Matematica)<BR><I>The
mathematics of viral hepatitis B and C </I><BR>A. d'Onofrio (Istituto Europeo di
Oncologia, Milano)<BR><A
href="http://www.dm.unipi.it/notiziario/index.php?op=view2&id=1368"></A><BR><FONT
color=#660033></FONT><BR><BR><B>Abstract:</B><BR>Probably the most important
case of a mathematical model that <BR>influenced medicine (both in basic
research and in clinics) is given <BR>by the mathematical models of HCV and HBV
dynamics and of antiviral<BR>therapies.<BR>I will review some of them (mainly
those by the Perelson's and <BR>Bonino's research groups, and mainly focusing on
HCV) by stressing <BR>the current "grand challenge":<BR>how to use and improve
those models in order to understand the <BR>problem of the disease-relapse
during and after the antivial <BR>therapies ?<BR>In particular, I will stress
how apparently abstract mathematical <BR>concepts (global asymptotic stability,
Floquet's eigenvalues, optimal <BR>control, hybrid gillespie algorithms, delay
differential equations) <BR>map into practical clinical problems (disease
erdication, drug <BR>schedulings, late and ultra-late disease relapse). </P>
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<P style="MARGIN-BOTTOM: 0cm"><I><FONT size=2><FONT face=Arial>Liviana Paoletti
<BR> Segreteria Scientifica</FONT></FONT></I></P>
<P style="MARGIN-BOTTOM: 0cm"><FONT size=2><FONT face=Arial><I>Dipartimento di
Matematica<BR>"L. Tonelli" Universita' di Pisa<BR>tel.
0502213251<BR>e-mail </I><A
href="mailto:paoletti@dm.unipi.it"><I>paoletti@dm.unipi.it</I></A></FONT></FONT></P><PRE></PRE></DIV></BODY></HTML>