Published Paper

Inserted: 1 mar 2024
Last Updated: 8 jan 2025

Journal: SIAM Journal on Mathematical Analysis
Volume: 57
Number: 1
Pages: 65-94
Year: 2025
Doi: https://doi.org/10.1137/24M1644523

Abstract:

In this paper we consider two diffuse interface models for tumor growth coupling a Cahn-Hilliard type equation for the tumor phase parameter to a reaction-diffusion type equation for the nutrient. The models are distinguished by the presence of two different coupling source terms. For such problems, we address the question of the limit, as the diffuse interface parameter tends to zero, from diffuse interface models to sharp interface ones, justifying rigorously what was deduced via formal asymptotics in 20. The resulting evolutions turn out to be varifold solutions to Mullins-Sekerka type flows for the tumor region suitably coupled with the equation for the nutrient.

Keywords: varifolds, Cahn-Hilliard equation, sharp interface, diffuse interface, Reaction-diffusion equation, Asymptotics, Tumor growth

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