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</o:shapelayout></xml><![endif]--></head><body lang=IT link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Segoe UI","sans-serif"'>Da:</span></b><span style='font-size:10.0pt;font-family:"Segoe UI","sans-serif"'> <a href="mailto:valeria.giuliani@sns.it">valeria.giuliani@sns.it</a> [<a href="mailto:valeria.giuliani@sns.it">mailto:valeria.giuliani@sns.it</a>] <br><b>Inviato:</b> martedì 10 giugno 2014 09:33<br><b>A:</b> 'docenti.scienze@sns.it'; 'ricercatori.scienze@sns.it'; Perfezionandi Scienze; Studenti Scienze; <a href="mailto:borsisti.scienze@sns.it">borsisti.scienze@sns.it</a>; Assegnisti Scienze; 'professoricontratto.scienze@sns.it'<br><b>Cc:</b> 'Classi'; Sito SNS; Portineria Carovana; Alessandro Viegi; 'Valeria Giusti'<br><b>Oggetto:</b> avviso Colloquio della Classe di Scienze prof. Jason Chin (19.06.2014)<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoTitle><span style='font-family:"Times New Roman","serif"'>Colloqui Classe di Scienze<o:p></o:p></span></p><p class=MsoTitle align=left style='text-align:left'><span style='font-size:10.0pt;font-family:"Times New Roman","serif"'><o:p><span style='text-decoration:none'> </span></o:p></span></p><h2><span style='font-family:"Times New Roman","serif"'>Giovedì 19 giugmo 2014<o:p></o:p></span></h2><p class=MsoNormal align=center style='margin-left:9.0pt;text-align:center;line-height:18.0pt'><span style='font-size:16.0pt'>ore 15:00<o:p></o:p></span></p><p class=MsoNormal align=center style='margin-left:9.0pt;text-align:center;line-height:18.0pt'><span style='font-size:16.0pt'><o:p> </o:p></span></p><p class=MsoNormal align=center style='margin-left:9.0pt;text-align:center;line-height:18.0pt'><u><span style='font-size:16.0pt'>Scuola Normale Superiore<o:p></o:p></span></u></p><p class=MsoNormal align=center style='margin-left:9.0pt;text-align:center;line-height:18.0pt'><span lang=EN-US style='font-size:16.0pt'>Pisa<o:p></o:p></span></p><p class=MsoNormal align=center style='margin-left:9.0pt;text-align:center;line-height:18.0pt'><span lang=EN-US style='font-size:16.0pt'>(Sala Azzurra)<o:p></o:p></span></p><p class=MsoNormal><b><u><span lang=EN-US style='font-size:10.0pt'><o:p><span style='text-decoration:none'> </span></o:p></span></u></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-US style='font-size:26.0pt'>Jason Chin</span></b><span lang=EN-US style='font-size:16.0pt'><br></span><i><span lang=EN-US style='color:black'>Head, Centre for Chemical & Synthetic Biology<o:p></o:p></span></i></p><p class=MsoNormal align=center style='text-align:center'><i><span lang=EN-US style='color:black'>Programme Leader, Division of Protein & Nucleic Acid Chemistry, <o:p></o:p></span></i></p><p class=MsoNormal align=center style='text-align:center'><i><span lang=EN-US style='color:black'>MRC Laboratory of Molecular Biology, Cambridge, UK<o:p></o:p></span></i></p><p class=MsoNormal style='text-autospace:none'><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=EN-US style='font-size:14.0pt'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span style='font-size:16.0pt'>Terrà un seminario dal titolo:<o:p></o:p></span></p><p class=MsoNormal style='text-align:justify'><i><o:p> </o:p></i></p><p class=MsoNormal style='text-align:justify'><i><o:p> </o:p></i></p><p class=MsoNormal align=center style='text-align:center;text-autospace:none'><b><span style='font-size:24.0pt'>“Reprogramming the Genetic Code”<o:p></o:p></span></b></p><p class=MsoNormal style='text-autospace:none'><b><span lang=EN-US><o:p> </o:p></span></b></p><p class=MsoNormal style='text-autospace:none'><b><span lang=EN-US style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal style='text-autospace:none'><b><span lang=EN-US>Abstract:<o:p></o:p></span></b></p><p class=MsoNormal><i><span lang=EN-US>The information for synthesizing the molecules that allow organisms to survive and replicate is encoded in genomic DNA. In the cell, DNA is copied to messenger RNA, and triplet codons (64) in the messenger RNA are decoded - in the process of translation - to synthesize polymers of the natural 20 amino acids. This process (DNA RNA protein) describes the central dogma of molecular biology and is conserved in terrestrial life. We are interested in re-writing the central dogma to create organisms that synthesize proteins containing unnatural amino acids and polymers composed of monomer building blocks beyond the 20 natural amino acids. I will discuss our invention and synthetic evolution of new 'orthogonal' translational components (including ribosomes and aminoacyl-tRNA synthetases) to address the major challenges in re-writing the central dogma of biology. I will discuss the application of the approaches we have developed for incorporating unnatural amino acids into proteins and investigating and synthetically controlling diverse biological processes, with a particular emphasis on understanding the role of post-translational modifications.<o:p></o:p></span></i></p><p class=MsoNormal style='text-autospace:none'><i><span lang=EN-US><o:p> </o:p></span></i></p><p class=MsoNormal style='text-align:justify'><span lang=EN-US style='font-size:16.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='text-align:justify'><span lang=EN-US style='font-size:16.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='text-align:justify'><span style='font-size:16.0pt'>Tutti gli interessati sono invitati a partecipare.<o:p></o:p></span></p><p class=MsoNormal style='text-align:justify'><span style='font-size:16.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='text-align:justify'><span style='font-size:16.0pt'>Classe di Scienze<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>