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<p class="MsoTitle"><span style="font-family:"Times New
Roman","serif"">Colloqui
Classe di Scienze<o:p></o:p></span></p>
<p class="MsoTitle" style="text-align:left" align="left"><span
style="font-size:
10.0pt;font-family:"Times New
Roman","serif""><o:p><span
style="text-decoration: none"> </span></o:p></span></p>
<h2><span style="font-family:"Times New
Roman","serif";mso-no-proof:yes">Mercoledė
26 giugno 2013</span><span style="font-family:"Times New
Roman","serif""><o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-left:9.0pt;text-align:center;
line-height:18.0pt;tab-stops:324.0pt" align="center"><span
style="font-size:16.0pt;font-family:
"Times New Roman","serif"">ore <span
style="mso-no-proof:yes">16:00</span><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:9.0pt;text-align:center;
line-height:18.0pt;tab-stops:324.0pt" align="center"><span
style="font-size:16.0pt;font-family:
"Times New Roman","serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:9.0pt;text-align:center;
line-height:18.0pt;tab-stops:324.0pt" align="center"><u><span
style="font-size:16.0pt;
font-family:"Times New Roman","serif"">Scuola
Normale Superiore<o:p></o:p></span></u></p>
<p class="MsoNormal" style="margin-left:9.0pt;text-align:center;
line-height:18.0pt;tab-stops:324.0pt" align="center"><span
style="font-size:16.0pt;font-family:
"Times New Roman","serif"">Pisa<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:9.0pt;text-align:center;
line-height:18.0pt;tab-stops:324.0pt" align="center"><span
style="font-size:16.0pt;font-family:
"Times New Roman","serif"">(Sala Azzurra)<o:p></o:p></span></p>
<p class="MsoNormal" style="tab-stops:324.0pt"><b><u><span
style="font-size:10.0pt;
font-family:"Times New Roman","serif""><o:p><span
style="text-decoration:none"> </span></o:p></span></u></b></p>
<p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:
auto;text-align:center;mso-pagination:none;mso-layout-grid-align:none;
text-autospace:none" align="center"><b
style="mso-bidi-font-weight:normal"><span
style="font-size:24.0pt;font-family:"Times New
Roman","serif";mso-ansi-language:
EN-US" lang="EN-US">Prof. Terence H. Rabbitts<br>
</span></b><i style="mso-bidi-font-style:normal"><span
style="font-family:"Times New
Roman","serif";mso-ansi-language:EN-US"
lang="EN-US">Weatherall
Institute of Molecular Medicine, MRC Molecular Haematology
Unit, University of
Oxford - Oxford, UK</span></i><span
style="font-family:"Times New
Roman","serif";
mso-ansi-language:EN-US" lang="EN-US"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:center;tab-stops:324.0pt"
align="center"><span
style="font-size:16.0pt;font-family:"Times New
Roman","serif"">Terrā un
seminario dal titolo:<o:p></o:p></span></p>
<p class="MsoNormal" style="tab-stops:324.0pt"><span
style="font-size:10.0pt;
font-family:"Times New Roman","serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="tab-stops:324.0pt"><span
style="font-size:10.0pt;
font-family:"Times New Roman","serif""><o:p> </o:p></span></p>
<pre style="text-align:center"><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:normal"><span style="font-size:24.0pt;
font-family:"Times New Roman","serif";mso-ansi-language:EN-US" lang="EN-US">“</span></i></b><b style="mso-bidi-font-weight:normal"><span style="font-size:24.0pt;
font-family:"Times New Roman","serif";mso-ansi-language:EN-US" lang="EN-US">Genes, the origins of cancer and pursuit of new therapies<i style="mso-bidi-font-style:normal">”</i><o:p></o:p></span></b></pre>
<p class="MsoNormal" style="text-align:justify"><span
style="mso-ansi-language:EN-US" lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><b
style="mso-bidi-font-weight:
normal"><i style="mso-bidi-font-style:normal"><span
style="font-family:"Times New
Roman","serif";mso-ansi-language:EN-US"
lang="EN-US">Abstract:</span></i></b><b
style="mso-bidi-font-weight:normal"><i
style="mso-bidi-font-style:normal"><span
style="font-size:11.0pt;font-family:"Times New
Roman","serif";
mso-ansi-language:EN-US" lang="EN-US"><o:p></o:p></span></i></b></p>
<p class="MsoNormal" style="text-align:justify"><i
style="mso-bidi-font-style:
normal"><span style="font-family:"Times New
Roman","serif";
mso-ansi-language:EN-US" lang="EN-US">Advances in molecular
biology have allowed us to
understand the structure-function relationship of genes and of
proteins and
their abnormal counterparts in human diseases such as cancer,
inflammatory
disease and neuropathies. We now understand a great deal about
the genetic
changes that underlie the origins of cancer and the subsequent
milieu of
mutations that characterize overt cancer but the translation
of this knowledge
into new therapies has been difficult. This is partly because
cancer cells
exploit many features of normal biology to extend longevity
and evade drug
treatment but also because perfecting drugs for intervention
requires many
layers of interaction between biologists, chemists and
physicians that present
practical difficulties. In our laboratory, we have been
attempting to circumvent
these limitations by creating a microcosm for developing new
methods for drug
target identification, through target validation to drug
discovery. I will
discuss some of this work in the context of our aim to employ
molecular biology
for improved treatment options for patients.<o:p></o:p></span></i></p>
<p class="MsoNormal" style="text-align:justify"><i
style="mso-bidi-font-style:
normal"><span style="font-family:"Times New
Roman","serif";
mso-ansi-language:EN-US" lang="EN-US"><o:p> </o:p></span></i></p>
<p class="MsoNormal" style="text-align:justify"><span
style="font-size:16.0pt;
font-family:"Times New Roman","serif"">Tutti
gli interessati sono invitati a
partecipare.<o:p></o:p></span></p>
<p class="MsoNormal"><i style="mso-bidi-font-style:normal"><span
style="font-size:16.0pt"><o:p> </o:p></span></i></p>
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<pre class="moz-signature" cols="72">--
--------------------------------------------------------------------------------
Valeria Giuliani
Scuola Normale Superiore
Servizio alla Didattica e Allievi
Tel. 050-509260
Piazza dei Cavalieri, 7
56126 Pisa
E-Mail: <a class="moz-txt-link-abbreviated" href="mailto:v.giuliani@sns.it">v.giuliani@sns.it</a>
E-Mail: <a class="moz-txt-link-abbreviated" href="mailto:adi.sd@sns.it">adi.sd@sns.it</a>
Le informazioni contenute nella presente e-mail e nei relativi allegati possono essere riservate e sono, comunque, destinate esclusivamente al destinatario in indirizzo.
E’ vietata, pertanto, la diffusione, distribuzione e/o copiatura di tali informazioni da parte di qualsiasi soggetto diverso dal destinatario.
Chiunque abbia ricevuto o letto questa e-mail per errore o senza esserne legittimato č invitato a darne immediatamente notizia al mittente tramite fax o e-mail e a distruggerla.
Grazie.
</pre>
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